Alveolar Type I Cells: Molecular Phenotype and Development
- 1 March 2003
- journal article
- review article
- Published by Annual Reviews in Annual Review of Physiology
- Vol. 65 (1) , 669-695
- https://doi.org/10.1146/annurev.physiol.65.092101.142446
Abstract
▪ Abstract Understanding of the functions and regulation of the phenotype of the alveolar type I epithelial cell has lagged behind studies of its neighbor the type II cell because of lack of cell-specific molecular markers. The recent identification of several proteins expressed by type I cells indicates that these cells may play important roles in regulation of cell proliferation, ion transport and water flow, metabolism of peptides, modulation of macrophage functions, and signaling events in the peripheral lung. Cell systems and reagents are available to characterize type I cell biology in detail, an important goal given that the cells provide the extensive surface that facilitates gas exchange in the intact animal.Keywords
This publication has 104 references indexed in Scilit:
- Caveolin-deficient mice: insights into caveolar function human diseaseJournal of Clinical Investigation, 2001
- Caveolae: A Once-Elusive Structure Gets Some RespectPublished by American Association for the Advancement of Science (AAAS) ,2001
- Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted MiceScience, 2001
- Activation of NF-kB mediates ICAM-1 induction in respiratory cells exposed to an adenovirus-derived vectorGene Therapy, 2001
- Tumor necrosis factor α-induced activation of downstream NF-κB site of the promoter mediates epithelial ICAM-1 expression and monocyte adhesion: Involvement of PKCα, tyrosine kinase, and IKK2, but not MAPKs, pathwayCellular Signalling, 2001
- Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem CellCell, 2001
- Cytosine methylation of an Sp1 site contributes to organ-specific and cell-specific regulation of expression of the lung epithelial gene T1αBiochemical Journal, 2000
- Caveolin-1 Expression and Caveolae Biogenesis during Cell Transdifferentiation in Lung Alveolar Epithelial Primary CulturesBiochemical and Biophysical Research Communications, 1999
- Chromosomal localization, genomic organization, and developmental expression of the murine caveolin gene family (Cav‐1, ‐2, and ‐3)FEBS Letters, 1998
- Characterization of the murine Icam-1 geneGenomics, 1992