Prevention of Compensatory Ovarian Hypertrophy by Local Treatment of the Ovary with 6-OHDA

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Abstract
The possible role of a neural mechanism involved in the development of compensatory ovarian hypertrophy was studied. A new technique, the use of a special plastic capsule, was developed to allow chronic local treatment of the ovary. Local treatment of 1 of the ovaries with 6-hydroxydopamine (6-OHDA) resulted in a weight increase in the other ovary. In the unilaterally ovariectomized rat the local application of 6-OHDA on the ovary blocked the development of compensatory ovarian hypertrophy. Local treatment of the ovary with dopamine (DA) did not interfere with the compensatory ovarian growth of the other ovary. Data suggest that intact adrenergic afferent and efferent neural elements of the ovary are required for the development of compensatory ovarian hypertrophy.