DELAY IN GROWTH AND THE DEVELOPMENT OF NEPHRITIS IN RATS TREATED WITH INTERFERON PREPARATIONS IN THE NEONATAL-PERIOD
- 1 January 1979
- journal article
- research article
- Vol. 95 (2) , 329-+
Abstract
Suckling rats were injected for 14-17 days with potent rat cell culture interferon preparations or various heterologous interferon or control preparations. Only treatment with rat interferon resulted in a delay in growth and maturation of different organs and the subsequent development of an immune complex type nephritis. Thus, 38 of 43 rats treated with rat interferon developed a severe glomerulonephritis; only 3 of 99 rats in the various control groups had minimal renal lesions. Deposits of Ig[immunoglobulin]G and C3 [complement component 3] along the glomerular basement membrane were only seen in interferon-treated rats.This publication has 21 references indexed in Scilit:
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