HUMAN-LEUKOCYTE INTERFERON PREPARATION BLOCKS GRANULOPOIETIC DIFFERENTIATION

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 54  (6) , 1423-1427
Abstract
Since interferon administration in the treatment of some malignant conditions was reported to cause leukopenia, the effects of human leukocyte interferon preparation (HLIF) on myelopoiesis in vitro were studied. The continual presence of HLIF in semisolid agar cultures caused a progressive decline in colony and a rise in cluster incidence with increasing concentrations of interferon. The total plating efficiency, remained nearly constant, regardless of the HLIF doses used. Morphological examination of the clusters demonstrated a progressively increasing percentage of immature granulocytic precursors with increasing HLIF concentrations. HLIF apparently causes leukopenia by blocking differentiation of marrow myeloid precursors.