INVESTIGATION OF THE HYPOTHALAMIC—PITUITARY—ADRENAL AXIS IN MESOMORPHIC TYPES OF PIG

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Abstract
Certain mesomorphic breeds and strains of pig characteristically show a marked acceleration of post-mortem glycolysis in muscle of up to 20 times that normally found. This is thought to be brought about in the living animal by the triggering of a hypersensitive myofibrillar ATPase activity which persists even when muscle relaxants are administered. The same pigs may also develop a fatal hyperpyrexia after exposure to halothane or succinyl choline. Several authors have suggested an alteration in the hormonal balance of susceptible animals and have laid particular emphasis on adrenal hypofunction (Lister, 1970). Differences in the patterns of post-mortem change in muscle can be demonstrated by treatments designed to modify tissue electrolyte balance (Passbach, Mullins, Wipf & Pane, 1970), but the evidence to support a notion of adrenal hypofunction as a causal agency in the syndrome is, in the main, of a circumstantial and indirect nature. We therefore used standard clinical

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