A novel, divergent simian T-cell lymphotropic virus type 3 in a wild-caught red-capped mangabey (Cercocebus torquatus torquatus) from Nigeria
- 1 October 2003
- journal article
- Published by Microbiology Society in Journal of General Virology
- Vol. 84 (10) , 2723-2727
- https://doi.org/10.1099/vir.0.19253-0
Abstract
We present here a novel, distinct simian T-cell lymphotropic virus (STLV) found in a red-capped mangabey (Cercocebus torquatus) (CTO-NG409), wild-caught in Nigeria, that showed an HTLV-2-like Western blot (WB) seroreactivity. The complete genome (8920 bp) of CTO-NG409 STLV was related to but different from STLV-3/PHA-PH969 (13·5 %) and STLV-3/PPA-F3 (7·6 %), and STLV-3/CTO604 (11·3 %), found in Eritrean and Senegalese baboons, and red-capped mangabeys from Cameroon, respectively. Phylogenetic analysis of a conserved tax (180 bp) sequence and the env gene (1482 bp) confirmed the relatedness of STLV-3/CTO-NG409 to the STLV-3 subgroup. Molecular clock analysis of env estimated that STLV-3/CTO-NG409 diverged from East and West/Central African STLV-3s about 140 900±12 400 years ago, suggesting an ancient African origin of STLV-3. Since phylogenetic evidence suggests multiple interspecies transmissions of STLV-1 to humans, and given the antiquity and wide distribution of STLV-3 in Africa, a search for STLV-3 in human African populations with HTLV-2-like WB patterns is warranted.Keywords
This publication has 19 references indexed in Scilit:
- Divergent Simian T-Cell Lymphotropic Virus Type 3 (STLV-3) in Wild-Caught Papio hamadryas papio from Senegal: Widespread Distribution of STLV-3 in AfricaJournal of Virology, 2003
- High Prevalence of Simian T-Lymphotropic Virus Type L in Wild Ethiopian BaboonsJournal of Virology, 2002
- Complete Sequence of a Novel Highly Divergent Simian T-Cell Lymphotropic Virus from Wild-Caught Red-Capped Mangabeys ( Cercocebus torquatus ) from Cameroon: a New Primate T-Lymphotropic Virus Type 3 SubtypeJournal of Virology, 2002
- Characterization of Novel Simian Immunodeficiency Viruses from Red-Capped Mangabeys from Nigeria (SIVrcmNG409 and -NG411)Journal of Virology, 2001
- Evidence for a Second Simian T-Cell Lymphotropic Virus Type 3 in Cercopithecus nictitans from Cameroon Journal of Virology, 2001
- Absence of evidence of infection with divergent primate T‐lymphotropic viruses in United States blood donors who have seroindeterminate HTLV test resultsTransfusion, 2000
- The discovery of two new divergent STLVs has implications for the evolution and epidemiology of HTLVsReviews in Medical Virology, 1999
- The presence of a divergent T-lymphotropic virus in a wild-caught pygmy chimpanzee (Pan paniscus) supports an African origin for the human T-lymphotropic/simian T-lymphotropic group of virusesJournal of General Virology, 1996
- A New Subtype of Human T-Cell Leukemia Virus (HTLV-II) Associated with a T-Cell Variant of Hairy Cell LeukemiaScience, 1982
- Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphomaProceedings of the National Academy of Sciences, 1980