Prenatal exposure to cocaine is associated with increased number of spine synapses in rat prelimbic cortex
- 13 July 2007
- Vol. 61 (10) , 862-865
- https://doi.org/10.1002/syn.20430
Abstract
Prenatal exposure to cocaine has been associated with cognitive deficits in children and in animal models. An excess activation of pyramidal neurons in the prefrontal cortex has been proposed as a potential cause for these deficits based on previous studies. The goal of this study was to determine if prenatal exposure to cocaine was associated with an increase in the number of excitatory synapses on dendritic spines in layer II/III of the prelimbic cortex. Frontal cortex of young adult male and female rats, exposed to either saline or cocaine (3 mg/kg i.e., twice a day, embryonic day 10–20), were examined using electron microscopy and the number of asymmetric spines synapses were estimated using the physical disector method. Both male and female rats prenatally exposed to cocaine had about twice as many synapses on dendritic spines as the prenatal saline controls. The increase in number of excitatory synaptic inputs associated with prenatal cocaine exposure could contribute to the increased neuronal activation and cognitive deficits noted. Synapse 61:862–865, 2007.Keywords
This publication has 24 references indexed in Scilit:
- Effects of Androgens and Estradiol on Spine Synapse Formation in the Prefrontal Cortex of Normal and Testicular Feminization Mutant Male RatsEndocrinology, 2007
- Prenatal exposure to cocaine selectively disrupts the development of parvalbumin containing local circuit neurons in the medial prefrontal cortex of the ratSynapse, 2005
- Short‐term treatment with the antidepressant fluoxetine triggers pyramidal dendritic spine synapse formation in rat hippocampusEuropean Journal of Neuroscience, 2005
- Male Rats Exposed to Cocaine in utero Demonstrate Elevated Expression of Fos in the Prefrontal Cortex in Response to EnvironmentNeuropsychopharmacology, 2002
- Prenatal cocaine exposure increases mesoprefrontal dopamine neuron responsivity to mild stressSynapse, 2001
- Prenatal exposure to cocaine reduces the number and enhances reactivity of A10 dopaminergic neurons to environmental stressSynapse, 2001
- Morphological Changes in Dendritic Spines Associated with Long-Term Synaptic PlasticityAnnual Review of Neuroscience, 2001
- Dose-response cocaine pharmacokinetics and metabolite profile following intravenous administration and arterial sampling in unanesthetized, freely moving male ratsNeurotoxicology and Teratology, 1997
- The unbiased estimation of number and sizes of arbitrary particles using the disectorJournal of Microscopy, 1984
- The formation of synaptic junctions in developing rat brain: A quantitative electron microscopic studyBrain Research, 1967