Relationship Between Penicillin Susceptibility and Virulence of Staphylococcus aureus.

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Abstract
No distinct correlation was established between penicillin susceptibility and virulence of 80 coagulase positive, hemolytic, mannitol fermenting strains of S. aureus. Both penicillin-resistant and penicillin-sensitive strains vary considerably in their mouse pathogenicity but a significantly higher proportion of the former proved to be virulent as compared to the latter which were fairly evenly divided between virulent and avirulent strains. No definite pattern with respect to change in virulence was observed with 4 originally penicillin-sensitive strains following artificial induction of resistance to the antibiotic.

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