COMPARISON OF THE EFFECTS OF ATROPINE AND GLYCOPYRROLATE ON LOWER OESOPHAGEAL SPHINCTER PRESSURE

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Abstract
The lower esophageal sphincter is thought to be an important mechanism in the prevention of reflux of gastric contents into the esophagus. Lower esophageal sphincter pressure (LOSP) was measured on 3 separate occasions in 9 healthy volunteers using esophageal pressure transducers. Atropine 0.6 mg decreased LOSP significantly at 5 min after i.v. injection (P < 0.025) and this change was sustained for 40 min. Glycopyrrolate 0.3 or 0.2 mg decreased LOSP significantly at 3 min after i.v. injection (P < 0.0025). This change was sustained for 60 min and was similar for both doses and also similar in magnitude to the change produced by atropine.