Role of parkin mutations in 111 community‐based patients with early‐onset parkinsonism
- 23 April 2002
- journal article
- Published by Wiley in Annals of Neurology
- Vol. 51 (5) , 621-625
- https://doi.org/10.1002/ana.10179
Abstract
Early-onset parkinsonism is frequently reported in connection with mutations in the parkin gene. In this study, we present the results of extensive genetic screening for parkin mutations in 111 community-derived early-onset parkinsonism patients (age of onset <50 years) from Germany with an overall mutation rate of 9.0%. Gene dosage alterations represented 67% of the mutations found, underlining the importance of quantitative analyses of parkin. In summary, parkin mutations accounted for a low but significant percentage of early-onset parkinsonism patients in a community-derived sample.Keywords
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