A Clinical Study of Elevated Platelet Adhesiveness and Accelerated Clot-Retraction Time

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Abstract
In a study of the platelet adhesiveness and clot retraction time in 500 patients, it was found that an elevated adhesiveness and a rapid clot retraction time were present in a variety of pathologic states. Abnormal values were demonstrated in patients with the following conditions: postoperative, posttraumatic, benign and malignant neoplasms, leukemia, polycythemia, granulating wounds, chromic dermatologic diseases, liver cirrhosis, thrombophlebitis and ACTH therapy. A hypothesis was suggested that a feature common to many of these diseases is an abnormally rapid growth of tissue. No relation was found between changes in the platelet adhesiveness, clot retraction time and thromboembolic phenomena.