RECOVERY OF THE INVIVO CYTO-TOXIC T-CELL RESPONSE IN CYCLOPHOSPHAMIDE-TREATED MICE BY INJECTION OF MIXED-LYMPHOCYTE-CULTURE SUPERNATANTS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 41  (9) , 3663-3665
Abstract
Mice given injections of high antileukemic doses of cyclophosphamide lost the capacity to generate cytotoxic T cells in vivo to allogeneic tumor cells. These low responses were not due to the elimination of cytotoxic T lymphocyte precursors because normal cytotoxic responses were obtained in vivo after cyclophosphamide treatment by injection of helper factor derived from mixed lymphocyte culture supernatants.