Effect of calcitonin on serum glucose concentration in rats.

Publisher Website
Google Scholar
Abstract
Calcitonin (CT) [porcine or salmon] administered s.c. to intact and thyroparathyroidectomized rats caused a significant decrease in serum Ca, while serum glucose concentration increased. The maximal response was obtained with 80 MRC mU[mouse radius calcifying milliunits]/100 g body wt. The lowest dose of CT which produces a detectable effect was approximately 20 MRC mU. Glucagon (5 .mu.g/100 g) caused a rapid elevation in serum glucose reaching a maximum level within 15 min, whereas CT caused a more gradual increase in serum glucose, reaching a maximum after 60 min. Administration of CT to fasted rats caused a significant increase in serum glucose. Liver glycogen levels were relatively decreased by CT administration. Administration of CT produced accumulation of Ca in liver cells and significantly elevated glucose-6-phosphatase and phosphorylase activities in liver homogenate. A rise in serum glucose concentration produced by CT may involve production of glucose in the liver.

This publication has 1 reference indexed in Scilit: