The effect of zinc on alkaline phosphatase activity in rheumatoid synovial tissue.
Open Access
- 1 December 1978
- journal article
- research article
- Published by Elsevier in Annals of the Rheumatic Diseases
- Vol. 37 (6) , 552-556
- https://doi.org/10.1136/ard.37.6.552
Abstract
To examine the reported beneficial effect of zinc in rheumatoid arthritis, rheumatoid synovial tissue has been maintained in vitro in non-proliferative culture with or without zinc sulphate in the culture medium. Alkaline phosphatase activity was measured by microdensitometry of the cytochemical reaction in cryostat sections; the activity in blood vessels was measured separately from that in the supporting tissue below the synovial surface. Zinc enhanced this activity optimally at concentrations of between 10(-5) and 10(-4) mol/l.Keywords
This publication has 14 references indexed in Scilit:
- Changes in alkaline phosphatase activity in periosteal cells in healing fracturesCalcified Tissue International, 1977
- Effect of glucocorticoids on the hexose monophosphate pathway in human rheumatoid synovial lining cells in vitro and in vivo.Annals of the Rheumatic Diseases, 1977
- ORAL ZINC SULPHATE IN RHEUMATOID ARTHRITISThe Lancet, 1976
- ZINC, PENICILLAMINE, AND RHEUMATOID ARTHRITISThe Lancet, 1976
- The inhibition of alkaline phosphatase by l-p-bromotetramisoleHistochemistry and Cell Biology, 1975
- Effect of glucocorticoids on lysosomes in synovial lining cells in human rheumatoid arthritis.Annals of the Rheumatic Diseases, 1974
- Trace metal composition of synovial fluid and blood serum of patients with rheumatoid arthritisJournal of Chronic Diseases, 1971
- COMPARATIVE METABOLISM OF COPPER AND ZINC IN PATIENTS WITH WILSONʼS DISEASE (HEPATOLENTICULAR DEGENERATION)The Lancet Healthy Longevity, 1967
- Diagnostic Criteria for Rheumatoid ArthritisAnnals of the Rheumatic Diseases, 1959
- The culture of mature organs in a synthetic mediumExperimental Cell Research, 1959