Synthesis of new polyfunctionally substituted pyridazines, phthalazines, cinnolines and thieno[3,4-c]pyridazines
- 1 January 1990
- journal article
- Published by Institute of Organic Chemistry & Biochemistry in Collection of Czechoslovak Chemical Communications
- Vol. 55 (12) , 2977-2986
- https://doi.org/10.1135/cccc19902977
Abstract
The reaction of ethyl 2-arylhydrazono-3-oxobutyrates (Ia, Ib) with active methylene ketones afforded pyridazin-5-carbonitrile derivatives. The methyl function in the ethyl pyridazin-3-carboxylate derivatives IIa, IIb reacted with arylidenemalononitrile to yield the phthalazine derivatives Va-Vf and with elemental sulfur to yield the thienopyridazines XIXa, XIXb. The cinnolines are producted from reaction of IIa, IIb with diethyl acetonedicarboxylate.Keywords
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