Dialysis, Neutropenia, Lung Dysfunction and Complement

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Abstract
The study in this issue of the Journal by Craddock and his colleagues provides an explanation for a problem first encountered a number of years ago: patients undergoing hemodialysis experience a transient neutropenia, in some cases accompanied by cardiopulmonary symptoms.1 2 3 Although leukopenia and thrombocytopenia had been noted during hemodialysis,2 it was Kaplow and Goffinet4 who called attention to the regular occurrence of neutropenia in these patients. Later, Brubaker and Nolph,5 in studies with neutrophils labeled with radioactive di-isopropylfluorophosphate (DF32P), described in more detail the kinetic changes responsible for neutropenia during dialysis. Neutropenia occurs within minutes after the start of . . .

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