Atrial natriuretic peptide vascular receptor: regulation of low-affinity binding by calcium
- 1 January 1989
- journal article
- research article
- Published by Portland Press Ltd. in Clinical Science
- Vol. 76 (1) , 9-11
- https://doi.org/10.1042/cs0760009
Abstract
1. In the presence of calcium, both high- [dissociation equilibrium constant (Kd) 5.8 .times. 10-11 mol/l] and low-(Kd 1.2 .times. 10-8 mol/l) affinity binding of atrial natriuretic peptide was detected on plasma membranes prepared from sodium-depleted rats. 2. In contrast, under calcium-free conditions only high-affinity binding (Kd 6.9 .times. 10-11 mol/l) was detected. 3. The requirement for calcium for low-affinity binding suggests a different mechanism of action than that for the high-affinity receptor.This publication has 5 references indexed in Scilit:
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