Flexible and Stereocontrolled Synthesis of Azasugars with Novel Substitution Patterns
- 1 January 1992
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1992 (12) , 999-1002
- https://doi.org/10.1055/s-1992-21562
Abstract
Polyhydroxylated piperidines (azasugars) with novel substitution patterns are synthesized in high diastereo- and enantiomeric excesses by α,α′ -double alkylation of 2,2-dimethyl- 1,3-dioxan-5-one using the SAMP-/RAMP-hydrazone method and subsequent piperidine ring formation through reductive amination.Keywords
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