Regional Cerebral Blood Flow during Bicuculline-Induced Seizures in the Newborn Piglet: Effect of Phenobarbital

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Abstract
The changes in cerebral blood flow (CBF) during and after bicuculline- induced seizures were studied by the radioactive microsphere technique in 12 newborn, urethan-anesthetized piglets, 6 piglets pretreated with phenobarbital (10 mg/kg) and 6 without phenobarbital. The mean arterial blood pressure (MABP), PaO(2), PaCO(2) and the cerebral tissue pH (CtpH) were measured. CBF was increased during seizure, more in basal ganglia (98 and 106% in the control and phenobarbital group, respectively) than in brainstem, cerebellum and cortex. 15 min after seizure, CBF has returned to preseizure values. There was no significant difference at any time between the control and phenobarbital group. The increase in CBF was correlated with an increase in MABP (r = 0.753, p < 0.01 ), suggesting a loss of cerebral autoregulation. CBF was significantly correlated with PaCO(2) before and after seizure, but not during seizure. Finally, the increase in CBF was significantly correlated with an early increase in CtpH (r = 0.570, p < 0.05), suggesting that brain acidosis is not involved in the pathogenesis of the increased CBF during seizures.