Protective effects of juzentaihoto, dried decoctum of 10 chinese herbs mixture, upon the adverse effects of mitomycin C in mice.

1 January 1983

journal article
research article
Published by Pharmaceutical Society of Japan in Journal of Pharmacobio-Dynamics

Vol. 6 (12) , 1000-1004
https://doi.org/10.1248/bpb1978.6.1000

Abstract

The effects of the Chinese prescription, Juzentaihoto (JTX), combined with mitomycin C (MMC) were studied with respect to the reduction of side effects and the enhancement of anticancer activity. JTX consisted of Astragali radix, Cinnamomi cortex, Rehmanniae radix, Paeonia radix, Cnidii rhizoma, Atractylodis lanceae rhizoma, Angelicae radix, Ginseng radix, Hoelen and Glycyrrhizae radix. In BDF1-mice which were implanted with P-388 leukemic cells, JTX prolonged significantly the average survival days of the MMC-treated group. In tumor-free BDF1-mice, JTX improved the leukopenia and the body weight loss which were caused by MMC. Additionally, JTX delayed the appearance of deaths caused by lethal doses of MMC. JTX apparently enhances the antitumor activity of MMC and lessens the adverse effects of it. JTX may be useful for patients undertaking MMC treatment.

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