Hormone-Sensitive Adenylate Cyclase in Human Colonic Mucosa
- 1 January 1978
- journal article
- research article
- Published by S. Karger AG in Digestion
- Vol. 17 (3) , 229-233
- https://doi.org/10.1159/000198114
Abstract
Human colonic adenylate cyclase has been shown to be sensitive to vasoactive intestinal polypeptide (VIP) and prostaglandins of the E- and F-type. Maximal activation of enzyme activity averaged 200% for VIP and 300–350% for the E-prostaglandins. Both classes of hormones had an additive effect on enzyme activity indicating the existence of two distinct hormone-sensitive adenylate cyclases in human colonic mucosa.Keywords
This publication has 4 references indexed in Scilit:
- Effect of Propranolol on Bile Acid- and Cholera Enterotoxin-Stimulated cAMP and Secretion in Rabbit IntestineGastroenterology, 1977
- Inhibition by Propranolol of Bile Acid Stimulation of Rabbit Colonic Adenylate Cyclase in VitroGastroenterology, 1976
- Bile acid stimulation of colonic adenylate cyclase and secretion in the rabbitDigestive Diseases and Sciences, 1976
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951