Endocrine Therapy of Functional Menometrorrhagia and Ovarian Sterility III. The Cyclic Administration of Equine Gonadotropin1

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Abstract
GONADOTROPIC THERAPY in anovulatory ovarian failure, in general, has been disappointing in its results. Of all the gonadotropins, the chorionic one of pregnancy urine has proven of least value. The consensus of most critical therapeutists is that it is incapable of inducing ovulation in this type of ovarian failure (1). An open minded attitude continues to prevail regarding the possible value of pituitary gonadrotropin although, as yet, extracts of pituitary gland containing this principle have not been available in such concentration and purity to warrant any serious therapeutic expectations. Equine gonadotropin, prepared from the serum of pregnant mares, despite the therapeutic expectations aroused by the clinical studies of Davis and Koff (2) which showed that augmentational phenomena were produced in normally responsive ovaries, has failed, in the opinion of many workers, to give good account of itself when used to treat the pathologic ovary. There has been considerable reliable clinical evidence that follicle stimulation and ripening and even striking cystic alterations may be produced in sensitive ovaries, but few critical data have been submitted that ovulation might be induced in ovaries not spontaneously exhibiting this function. The present communication, and the one to follow, attempt to evaluate the therapeutic efficiency of equine gonadotropin in anovulatory ovarian failure.

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