(+)-Phorboxazole A Synthetic Studies. A Highly Convergent, Second Generation Total Synthesis of (+)-Phorboxazole A
- 1 September 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 7 (20) , 4399-4402
- https://doi.org/10.1021/ol051584i
Abstract
A second generation total synthesis of the potent antitumor agent (+)-phorboxazole A (1) has been achieved. The cornerstone of this approach comprises a more convergent strategy, involving late-stage Stille union of a fully elaborated C(1−28) macrocycle with a C(29−46) side chain. The second generation synthesis entails the longest linear sequence of 24 steps, with an overall yield of 4.2%.Keywords
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