Studies on the mutagenicity of Swertiae Herba. II. Quantitative analysis of mutagenic components by thin layer chromatograph densitometry.
- 1 January 1984
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 32 (12) , 4942-4945
- https://doi.org/10.1248/cpb.32.4942
Abstract
Good separation of 7 mutagenic xanthones [methylbellidifolin, methylswertianin, swertianin, bellidifolin, norswertianin, desmethylbellidifolin and 5,8-dimethylbellidifolin] present in Swertiae Herba [Swertia japonica] was accomplished by TLC on silica gel plates. The conditions for quantitative analysis of these xanthones by TLC-densitometry were investigated, and this TLC-densitometry was applied to the analysis of the constituents of the commercial Swertiae Herba and to the determination of the time courses of their extraction with hot water. The relationship between exanthone content and mutagenicity is discussed.This publication has 3 references indexed in Scilit:
- Studies on the mutagenicity of Swertiae Herba. I. Identification of the mutagenic components.CHEMICAL & PHARMACEUTICAL BULLETIN, 1984
- Mutagenic activities of gentisin and isogentisin from Gentianae radix (Gentianaceae)Mutation Research/Genetic Toxicology, 1983
- Fecalase: a model for activation of dietary glycosides to mutagens by intestinal flora.Proceedings of the National Academy of Sciences, 1980