Increased Risk of Testicular Germ Cell Cancer Among Infertile Men

Top Cited Papers
Open Access
Publisher Website
Google Scholar
Abstract
Testicular germ cell cancer is the most common cancer among young men in industrialized countries. During the last 3 to 5 decades, there has been a notable and continued increase in the incidence of testicular germ cell cancers in men. Among US men, incidence has increased from 3.8 to 6.8 cases per 100 000 person-years in whites from 1975 to 2002.1 More profound increases have been seen in Scandinavian countries such as Norway, where incidence has increased from 3.5 to 10 cases per 100 000 person-years from 1960 to 2000.2 During the same period, there is evidence of a decline in semen quality and fertility in industrialized nations.3,4 However, it is unclear whether these 2 trends are independent or related to one another.