THEORY OF THYROID HORMONE ACTION
- 1 December 1953
- journal article
- research article
- Published by American Medical Association (AMA) in A.M.A. Archives of Internal Medicine
- Vol. 92 (6) , 880-888
- https://doi.org/10.1001/archinte.1953.00240240116008
Abstract
STUDIES of synthetic sodium/-thyroxine demonstrate that as an oral medication in dosage of 0.5 mg. or less daily it is calorigenic and clinically active.1In similar dosage it has been shown to reduce the uptake of radioactive iodine.2Triiodothyronine, recently identified, synthesized, and demonstrated in human serum,3also has been shown to be clinically effective4and to be several times as potent as thyroxine.5 Curiosity as to the possible effect of sodiumd-thyroxine led us to carry out tests with this substance. It was difficult to obtain. Dr. Leonard Ginger, of the Baxter Laboratories, Inc., Morton Grove, Ill., the source of the levo form used in our clinical studies, produced it for us. It has already been demonstrated by Greer6that inorganic iodine in amounts equal to that in these medications has no effect upon uptake of radioactive iodine. We have, however, carried out a few tests at four-doseThis publication has 0 references indexed in Scilit: