Immunology of Interferons

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Abstract
Human interferons prepared by uv-irradiated Newcastle disease virus (NDVuv) in six different cell types protected cultures of primary rabbit kidney cells at least as well as human foreskin fibroblasts against challenge with vesicular stomatitis virus. In addition, interferon obtained from human peripheral leukocytes protected L cells in low dilution. At adequate dose levels, all human interferons tested primed NDVuv-induced interferon production in L cells. The heterospecific antiviral resistance promoted by human interferons in rabbit cells is not enhanced by treatment of the cultures with various polyionic compounds. The heterospecific protecting and priming effects of human interferons are neutralized by antibodies against rabbit and mouse cell interferons. The findings indicate that common antigens are shared by these three interferons, which may explain the unorthodox behavior of human interferons in heterologous systems.

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