A NEW ANTI-LIVER KIDNEY MICROSOME ANTIBODY (ANTI-LKM2) IN TIENILIC ACID-INDUCED HEPATITIS

  • 1 January 1984
    • journal article
    • research article
    • Vol. 55  (3) , 561-570
Abstract
The sera of 131 patients with anti-liver-kidney microsome antibodies (anti-LKM) detected between 1973 and 1979 in 2 different laboratories were re-examined. Eighty-six anti-LKM corresponded to the description given by Rizzetto, Swana and Doniach, with a pattern of fluorescence predominating on the 3rd portion of the proximal tubles (P3). This group comprised 45 cases of idiopathic chronic hepatitis or idiopathic cirrhosis and 1 case of holathane-induced hepatitis. Anti-LKM (45) gave a different pattern on male mouse liver and male rat kidney: fluorescence was greater on centrolobular than on periportal hepatocytes; the 1st and 2nd portions of proximal tubles (P1 and P2) predominated over P3; P1 fluorescence was as equally intense as P2 and P3 cells were heterogeneous with 1 cell of 20 more positive than the rest. Absorption tests confirmed that the corresponding antigen was also present in the liver microsomal fraction. A retrospective clinical study discovered tienilic acid-induced hepatitis in all cases. It was suggested that this new antibody be named anti-LKM2.