The c-Abl tyrosine kinase contributes to the transient activation of MAP kinase in cells plated on fibronectin
- 29 June 2000
- journal article
- Published by Springer Nature in Oncogene
- Vol. 19 (28) , 3216-3219
- https://doi.org/10.1038/sj.onc.1203667
Abstract
Previous work showed that integrin stimulation triggers activation of the c-Abl tyrosine kinase and its transient localization to focal adhesions. We now report that plating cells on fibronectin triggers association of Grb2 with c-Abl, suggesting possible involvement of c-Abl with integrin activation of the MAP kinase pathway. Expression of a kinase-defective c-Abl specifically inhibited the transient induction of Erk2 activity following cell adhesion. Together with the known ability of activated, oncogenic forms of c-Abl to activate Ras and the MAP kinase pathway, these data suggest that c-Abl contributes to the integrin induction of MAP kinase activity.Keywords
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