Transforming Growth Factor-β Isoforms Expressions in Pulmonary Adenocarcinomas as Prognostic Markers
- 1 January 1997
- journal article
- laboratory investigation
- Published by S. Karger AG in Oncology
- Vol. 54 (2) , 122-128
- https://doi.org/10.1159/000227675
Abstract
The transforming growth factor (TGF)-β1, TGF-β2 and TGF-β3 expressions were immunohistologically studied in tissues specimens from 120 patients with a pulmonary adenocarcinoma. The results of a univariate analysis indicated that the expression of each of the TGF-β isoforms correlated with the prognosis. Of the three prognostic factors examined using Cox’s stepwise regression model, the TGF-β1 isoform was found to correlate with survival. These findings suggest that TGF-β isoforms play an important role in tumor progression and that the TGF-β1 isoform is a useful prognostic marker for pulmonary adenocarcinomas.Keywords
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