Increased Lysosomal Enzymes in Lungs of Ozone-Exposed Rats

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Abstract
Groups of rats were exposed continuously for five days at 0.7 ± 0.15 ppm ozone or for seven days at 0.79 ± 0.14 ppm ozone. The specific activities of the lysosomal hydrolases, acid phosphatase; β-N-acetylgIucosaminidase; cathepsins A, B, C, and D; and benzoylarginine-β-naphthyIamide (BANA) amidohydrolase, were measured In whole lung homogenates, cell-free particulates or light mitochondrial fractions, and in the supernatant fractions. Statistically significant increases in the specific activities of these hydrolases from the lungs of ozone-exposed rats were observed over those from control animals. The cause of the increases can be attributed to the infiltration of the lung by phagocytic cells In the inflammatory response induced by ozone. The increase in specific activities of the proteases and peptidases in the lungs is of significance when related to chronic obstructive pulmonary disease and cases of genetic deficiency of α1-antitrypsin factor.

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