Total Spontaneous Resolution of Chiral Covalent Networks from Stereochemically Labile Metal Complexes
- 29 August 2005
- journal article
- research article
- Published by Wiley in Chemistry – A European Journal
- Vol. 11 (18) , 5311-5318
- https://doi.org/10.1002/chem.200500094
Abstract
Stereochemically labile copper and zinc complexes with the N,N′-dimethylethylenediamine ligand (dmeda) have been shown to be promising precursors for the total spontaneous resolution of chiral covalent networks. (N,N′)-[Cu(NO3)2(dmeda)]∞ crystallises as a conglomerate and yields either enantiopure (R,R)-1 or enantiopure (S,S)-1. A mixed-valence copper(I/II) complex, [{CuIIBr2(dmeda)}3(CuIBr)2]∞ (2), which crystallises as a pair of interpenetrating chiral (10,3)-a nets, is formed from CuBr, CuBr2 and dmeda. One net contains ligands with solely (R,R) configuration and exhibits helices with (P) configuration while the other has solely (S,S)-dmeda ligands and gives rise to a net in which the helices have (M) configuration. The whole crystalline arrangement is racemic, because the interpenetrating chiral nets are of opposite handedness. With zinc chloride (R,S)-[ZnCl(dmeda)2]2[ZnCl4] (3) is obtained, which is a network structure, although not chiral. Total spontaneous resolution of stereochemically labile metal complexes formed from achiral or racemic building blocks is suggested as a viable route for the preparation of covalent chiral networks. Once the absolute structure of the compound has been determined by X-ray crystallography, a quantitative determination of the enantiomeric excess of the bulk product can be undertaken by means of solid-state CD spectroscopy.Keywords
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