Hypouricemia due to Increased Tubular Urate Secretion
- 1 January 1987
- journal article
- research article
- Published by S. Karger AG in Nephron
- Vol. 45 (1) , 31-34
- https://doi.org/10.1159/000184067
Abstract
A 45-year-old woman had hypouricemia (serum uric acid, 1.0–2.3 mg/dl) with increased uric acid clearance (29.8 ± 9.3 ml/min/1.73 m2). Uric acid clearance to creatinine clearance ratio (Cua/Ccr) was suppressed markedly by pyrazinamide to 2.3% and surprisingly enhanced by probenecid to 227.8%. No other renal tubular or metabolic abnormalities were detected. This previously unreported high postprobenecid Cua/Ccr suggests that markedly increased urate secretion by the renal tubule is responsible for hypouricemia in this patient.Keywords
This publication has 3 references indexed in Scilit:
- Hypouricemia due to an increment in renal tubular urate secretionArchives of internal medicine (1960), 1982
- Origins of the Uricosuric ResponseJournal of Clinical Investigation, 1973
- Hypouricemia in Hodgkin's DiseaseAnnals of Internal Medicine, 1972