Mechanism of the Antidiuretic Action of Reserpine.
- 1 January 1962
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 109 (1) , 32-35
- https://doi.org/10.3181/00379727-109-27095
Abstract
The urinaxy excretion of electrolytes, chlorides and 5-hydroxy-indolylacetic acid (5-HIAA) after administration of either reserpine or serotonin in dogs was closely similar in pattern: lower Na+ and Cl-, and higher K+ and 5-HIAA. Antidiuretic hormone (ADH) administration, on the other hand, resulted in a different pattern: higher Na+ and Cl-, and lower K+ and 5-HIAA. This suggests that the antidiuretic action of reserpine is due to release of serotonin, depleted from body stores, and not to release of ADH.Keywords
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