Effects of organotin compounds on maximal electroshock seizure (MES) responsiveness in mice. II. Tricyclohexyltin and triphenyltin

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Abstract
Male mice (25-30 g) were injected (i.p.) with 0, 3.5 .times. 10-6, 17.5 .times. 10-6 or 26.25 .times. 10-6 mol/kg of tricyclohexyltin bromide (TCT) [acaricide] or triphenyltin acetate (TPhT) [fungicide] in a corn-oil vehicle. The mice were tested for maximal electroshock seizure (MES) at 0.5, 4, 24 and 96 h following exposure to the organotin compounds, and the durations of seizure phases were measured and used to assess seizure severity. No significant changes in seizure-grade distribution were observed in any TCT- or TPhT-treated groups at any time point. No significant changes in the duration of seizure phases, as compared to controls, were observed in animals dosed with 3.5 .times. 10-6 mol/kg TCT or TPhT at any time point. At 0.5 h following exposure, the mice dosed with the 2 higher levels of TCT or TPhT exhibited increases in MES severity. At 4 and 24 h following exposures, the mice exposed to the 2 higher dose levels of TPhT exhibited decreases in MES severity, followed by a recovery of normal seizure severity at 96 h. The animals dosed with the higher dose levels of TCT exhibited at increased MES severity at 4, 24 and 96 h following exposure. At equimolar doses TCT and TPhT possessed a different spectrum of action than the tri-n-alkyltins.