Design of Aerosol Delivery Systems to Optimize Regional Deposition and Agent Utilization

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Abstract
Aerosol delivery systems serve several functions including use in toxicological investigations, therapeutics, diagnosis of respiratory behavior, determination of airway dimensions, study of defenses, and provision of data for dosimetry models. Presently used systems fall into two classes, small-simple and large-complex. There is a need to develop new systems for specific functional applications. The components of a delivery are considered and a number of new approaches are suggested which ought to improve the predictability of regional delivery in the respiratory tract as well as optimize utilization of agents which may be costly or in small supply.