Effect of valproic acid on 5−hydroxytryptamine turnover in mouse brain
- 1 March 1985
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 37 (3) , 199-200
- https://doi.org/10.1111/j.2042-7158.1985.tb05040.x
Abstract
The effect of the antiepileptic drug valproic acid (di-n-propylacetic acid, 200 mgkg−1) on brain 5−hydroxytryptamine (5−HT) synthesis during monoamine oxidase inhibition by pargyline hydrochloride (120 mg kg −1) was studied in mice. Valproic acid increased 5−HT synthesis and elevated 5−hydroxyindoleacetic acid level in brain indicating that turnover of 5−HT is increased. The possible significance of this effect in relation to anticonvulsant action of valproic acid is discussed.Keywords
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