Direct Separation of D-and L-Sotalol Mandelate and Hydrochloride Salts by High Performance Liquid Chromatography
- 1 October 1987
- journal article
- research article
- Published by Taylor & Francis in Journal of Liquid Chromatography
- Vol. 10 (13) , 3015-3023
- https://doi.org/10.1080/01483918708066843
Abstract
A method was developed specifically to determine the purity of d- and 1-sotalol mandelate salts during resolution of the racemic mixture. This procedure provides a useful means of monitoring directly the purity of the salt and the composition of the mother liquors at each step of purification.Keywords
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- Chiral Separation of Cationic Drugs on an α1-Acid Glycoprotein Bonded Stationary PhaseJournal of Liquid Chromatography, 1986
- Resolution of the enantiomers of propranolol and other beta-adrenergic antagonists by high-performance liquid chromatographyJournal of Chromatography B: Biomedical Sciences and Applications, 1983