Treatment of a Metastatic Prostate Derived Tumor with Surgery and Chemotherapy

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Abstract
The R3327/MAT-Lu tumor is a metastasizing variant of the Dunning R3327 Copenhagen rat prostatic carcinoma which, when implanted s.c. in the flank or i.m. in the hind leg, invariably metastasizes to the lungs. Treatment with single dose chemotherapy, surgical excision of the primary tumor or a combination of tumor excision and postperative single dose chemotherapy was examined. All 3 regimes significantly reduced the number of lung metastases, but only the combination of tumor excision followed by postoperative chemotherapy substantially prolonged survival and produced cures.