Characterization of the .BETA.-adrenoceptors in coronary vasculature of the dog heart.

1 January 1982

journal article
research article
Published by International Heart Journal (Japanese Heart Journal) in Japanese Heart Journal

Vol. 23 (1) , 113-118
https://doi.org/10.1536/ihj.23.113

Abstract

The .beta.-adrenoceptors of dog coronary vasculature were characterized. Blockade of .beta.1-adrenoceptors with ICI 50172 [practolol] or .beta.2-adrenoceptors with RB2 [1-(2,4-dimethylaniline)-3-isopropylamino-2-propranolol] showed only partial antagonism of isoprenaline-induced decrease in coronary resistance. Combined treatment with ICI 50172 and RB2 completely blocked the isoprenaline-induced fall in coronary resistance. Essentially similar results were observed in controlled heart rate experiments where the drugs were administered locally into the coronary circulation. The involvement of both .beta.1 and .beta.2 adrenoceptors in isoprenaline-induced coronary vasodilatation was demonstrated.

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