New Phenolic Metabolites from Gliocladium roseum.

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Abstract
Orcinol and 1,3-dihy-droxy-4-5-dimethylbenzene have been siolated from a certain strain of Glicocladium roseum, known to produce aurantioglicoladin and related quinones. l,3-Dihydroxy-4,5-dimethylbenzene, which has not previously been reported as a mould metabolic product, was found to be biosynthesized by the acetate-polymalonate pathway, with introduction of a methyl group from the C1-pool. The tow phenols isolated seem to be derived from orsellinic acid and 2,4-dihydroxy-5,6-dimethyl-benzoic acid, respectively, which were found to be rapidly metabolized in the mould, mainly by decarboxylation. Neither of the phenolic acids could, therefore, normally be detected in G. roseum cultures, but occassionally 2,4-dihydroxy-5,6-dimethylbenzolic acid was identified as a metabolic product of the mould.