Studies with Mouse Pituitary Thyrotropic Tumors. II. Restored Responsiveness in Semi-Responsive Strain Surgically Reduced in Size.

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Abstract
Implants of an autonomous semi-responsive strain of mouse pituitary thyrotropic tumor, L24, grown in radiothyroidectomized mice to a weight of 2 g, or more lost their responsiveness to thyroxine. When these were reduced in size surgically to a diameter of about 0.5 cm and the hosts fed thyroxine, no tumor became palpable over the space of 30 days, although the expected increase in tumor size occurred in similarly operated, untreated controls. The suppressed tumors promptly grew in the thyroxine-treated group when administration of the hormone was stopped.