Structure–Activity Relationship of theWarburgiaSesquiterpene Dialdehydes
- 1 January 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in Agricultural and Biological Chemistry
- Vol. 48 (1) , 73-78
- https://doi.org/10.1080/00021369.1984.10866095
Abstract
Sesquiterpene dialdehydes, isolated originally as insect antifeedants from East African Warburgia trees, have been shown to exhibit strong antimicrobial activity. Their chemical reactivities and biological activities were investigated in comparison with those of related compounds. There was a good correlation between the antifungal activity and the papain inhibitory activity of these compounds. Both activities appear to result from their highly specific reactivity with sulfhydryl groups. Consideration of the structure–activity relationships led to the proposal of a structure unit, the enal–aldehyde moiety, that is essential to biological activity.This publication has 4 references indexed in Scilit:
- Physiological Activity of Warburganal and Its Reactivity with Sulfhydryl GroupsThe Journal of Biochemistry, 1983
- Insect antifeedant terpenes, hot-tasting to humansCellular and Molecular Life Sciences, 1981
- Potent army worm antifeedants from the east African Warburgia plantsJournal of the Chemical Society, Chemical Communications, 1976
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951