EFFECT OF PROSTACYCLIN (PGI2) ON PLATELET BEHAVIOR - THROMBUS FORMATION INVIVO AND BLEEDING-TIME

  • 1 January 1979
    • journal article
    • research article
    • Vol. 41  (2) , 425-435
Abstract
PGI2 infused i.v. into anesthetized rabbits inhibited electrically-induced thrombus formation in the carotid artery, increased bleeding time and inhibited ex vivo platelet aggregation induced by ADP or arachidonic acid. The increase in bleeding time and the inhibition of ex vivo platelet aggregation lasted for as long as the infusion of PGI2 was maintained but rapidly disappeared after infusion was stopped. PGI2 was more potent inhibitor of platelet function, in vivo than prostaglandin [PG] E1 or PGD2. The effects of PGI2 on all parameters studied except blood pressure were potentiated by the concomitant administration of theophylline, a phosphodiesterase inhibitor.