Tick Repellent Investigations at Bull's Island, S. C., 19481

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Abstract
Field tests of repellents were conducted from March through July 1948. They were applied to regulation army fatigue uniforms worn in areas heavily infested with the lone star tick, Amblyomma americanum. The more effective compounds that have been indicated safe for use on skin or clothing, and caused no irritation in these tests, were the butyl ester of 3,4-dihydro-2,2-dimethyl-4-oxo-l,2H-pyran-6-carboxylic acid (Indalone), 2-phenoxy-ethyl isobutyrate, hexyl mandelate, and ethyl beta-phenylhydracrylate. Indalone was the most consistently effective. Other compounds, outstanding for effectiveness alone, were very toxic when applied directly to the skin. Acetone solns. of Indalone produced more effective impregnations than emulsions, but both formulations with 2-[2-(-ethylhexyloxy) ethoxy] ethanol and dimethyl carbate were about equal. Treatment of uniforms with powders of Indalone and 2-[2-(-ethylhexyloxy) ethoxy] ethanol (0.1 g. per sq. ft.) gave fair to good protection for a single wearing.

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