Effect of consumption of a ready-to-eat breakfast cereal containing inulin on the intestinal milieu and blood lipids in healthy male volunteers
Open Access
- 1 September 1999
- journal article
- clinical trial
- Published by Springer Nature in European Journal of Clinical Nutrition
- Vol. 53 (9) , 726-733
- https://doi.org/10.1038/sj.ejcn.1600841
Abstract
Objective: To investigate the effect of a breakfast cereal containing inulin on blood lipids and colonic ecosystem in normolipidemic young men. Setting: Department of Food Science and Microbiology,University of Milan, Italy. Subjects: Twelve healthy male volunteers, age 23.3±0.5 y, body mass index (BMI) 25.7±1.2 kg/m2 (mean±s.e.m.). Interventions: Subjects consumed daily, for three periods of four weeks, 50 g of a rice-based ready-to-eat cereal (placebo) and the same cereal containing 18% inulin (test) in substitution of their habitual breakfast, then returned to the habitual diet (wash-out). They followed no other dietary restrictions. Results: No changes in body weight, dietary habits, faecal and bile acid output, faecal short-chain fatty acid (SCFA) and faecal pH, were observed at the end of each period, whereas plasma total cholesterol and triacylglycerols significantly decreased at the end of test period by 7.9±5.4 (PP2 excretion (IAUC test 280±40; placebo 78±26 ppm·h, PPP<0.05). Conclusions: Inulin seems to have a lipid lowering potential in normolipidemic men possibly mediated by mechanisms related to colonic fermentation. Sponsorship: National Research Council of Italy, grant number 95.00773.PF41.Keywords
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