Cyclosporine and hypertension

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Abstract
Transplant physicians frequently encounter hypertension as a clinical problem since the widespread use of cyclosporine was established in 1983. While hypertension had been a problem before cyclosporine, this immunosuppressive agent is capable of causing a different form of post‐transplant hypertension. Cyclosporine‐induced hypertension doesn't appear to be mediated by the renin‐angiotensin system and may be associated with vascular volume expansion. The current study observes 50 kidney transplant patients documented to have hypertension while on cyclosporine therapy. Follow‐up of these patients suggests that the hypertensive state does not resolve with time as long as cyclosporine blood levels are maintained.