Influence of Blood pH on Procaine Toxicity
- 31 March 1956
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 185 (1) , 69-70
- https://doi.org/10.1152/ajplegacy.1956.185.1.69
Abstract
Groups of mice were rendered acidotic by injections of acetazoleamide (1.0 gm/kg) and alkalotic by injections of NaHCO3 (2.0 gm/kg). Dosage-mortality curves showed procaine toxicity to be increased in acidotic mice and decreased in alkalotic mice as compared to controls. The effect of acid-base balance disturbance on the convulsant effect of procaine was not sufficiently clear-cut to permit conclusions to be drawn. The effects seen probably reflect changes in the cardiotoxic action of procaine.Keywords
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