Effects of 8-Isoprostaglandin E1 on the Systemic and Pulmonary Circulations in Dogs

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Abstract
The effects of 8-iso-prostaglandin E1 on the systemic and pulmonary circulations were studied and compared with those of PGE1 and PGF2α in anesthetized dogs. It was found that the iv administration of 8-iso-PGE1 decreased systemic arterial pressure slightly and increased heart rate and myocardial contractile force slightly. The magnitude of the systemic hypotensive effect of 8-iso-PGE1 was equivalent to approximately 1/125 to 1/250 of that of PGE1 in dogs. On the other hand, the pulmonary hypertensive action of 8-iso-PGE1 was 5 times greater than that of PGE1. The present study indicates that 8-iso-PGE1 increases pulmonary arterial pressure through its vasoconstrictor action on the pulmonary vascular bed.

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