GOLD COMPOUNDS IN TREATMENT OF EXPERIMENTAL TUBERCULOSIS OF SKIN IN ANIMALS

1 January 1926

journal article
research article
Published by American Medical Association (AMA) in Archives of Dermatology and Syphilology

Vol. 13 (1) , 43-54
https://doi.org/10.1001/archderm.1926.02370130046004

Abstract

Paracélsus, in 1500, compounded an "elixir of life" made up of gold and mercury, and the use of gold in tuberculosis probably dates back to this time. In 1810, Chrestien, according to White,¹reintroduced the use of gold in tuberculosis. The use of compounds of gold in the treatment of tuberculosis had, however, its scientific inception in the statement of Robert Koch before the Tenth International Congress of Berlin in 1890. He stated that various salts of gold, especially potassium-gold cyanid, exercised an extremely injurious effect on the tubercle bacillus, preventing its growth in dilutions of 1: 1,000,000. Von Behring²confirmed Koch's findings, but found that in blood serum the bacteriostatic effect of gold salts was considerably reduced, owing to the presence of the globulins. Bruck and Glück³were the first in recent years to institute gold treatment in tuberculosis. These investigators tried the effect of intravenous

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